Capitalizing on the Teachable Moment: Osteoarthritis Physical Activity and Exercise Net for Improving Physical Activity in Early Knee Osteoarthritis

BackgroundPractice guidelines emphasize the use of exercise and weight reduction as the first line of management for knee osteoarthritis (OA).However, less than half of the people with mild OA participate in moderate intensity physical activity.Given that physical activities have been shown to reduce pain, improve quality of life, and have the pote

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Exosomes derived from pulmonary metastatic sites enhance osteosarcoma lung metastasis by transferring the miR-194/215 cluster targeting MARCKS

Osteosarcoma, a prevalent primary malignant bone tumor, often presents with lung metastases, severely impacting patient survival rates.Extracellular vesicles, particularly exosomes, play a pivotal role in the formation and progression of osteosarcoma-related pulmonary lesions.However, the communication between primary osteosarcoma and exosome-media

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Neuroendocrine Immunoregulation in Multiple Sclerosis

Currently, it is generally accepted that multiple sclerosis (MS) is a complex multifactorial disease involving genetic and environmental factors affecting the autoreactive immune responses that lead to damage of myelin.In this respect, intrinsic or extrinsic factors such as emotional, psychological, traumatic, or inflammatory stress as well as belt

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