BackgroundPractice guidelines emphasize the use of exercise and weight reduction as the first line of management for knee osteoarthritis (OA).However, less than half of the people with mild OA participate in moderate intensity physical activity.Given that physical activities have been shown to reduce pain, improve quality of life, and have the pote
Exosomes derived from pulmonary metastatic sites enhance osteosarcoma lung metastasis by transferring the miR-194/215 cluster targeting MARCKS
Osteosarcoma, a prevalent primary malignant bone tumor, often presents with lung metastases, severely impacting patient survival rates.Extracellular vesicles, particularly exosomes, play a pivotal role in the formation and progression of osteosarcoma-related pulmonary lesions.However, the communication between primary osteosarcoma and exosome-media
Neuroendocrine Immunoregulation in Multiple Sclerosis
Currently, it is generally accepted that multiple sclerosis (MS) is a complex multifactorial disease involving genetic and environmental factors affecting the autoreactive immune responses that lead to damage of myelin.In this respect, intrinsic or extrinsic factors such as emotional, psychological, traumatic, or inflammatory stress as well as belt
The effect of high tone external muscle stimulation on polyneuropathy: a systematic review and meta-analysis
Background and study aim.High-tone therapy, also known as High-Frequency External Muscle Stimulation (HTEMS), is a more recent and unique form of electrotherapy treatment.Unlike traditional electrotherapy methods, which use a single frequency, high-tone therapy modulates both frequency and amplitude to deliver more energy to the tissues.The options
Leveraging Healthcare Opportunities for Improved Access among Ghanaian Retirees: The Case of Active Aging
This paper is a policy brief with targeted interviews of older adults in urban Ghana with recommendations for future healthcare policy.Using qualitative explorative approach, the scope of the research is to examine opportunities that focus on healthy aging in order to enhance healthcare infrastructure in Ghana in preparation for an increased number